Jeff Axline

Executive Director, Supply Chain Strategy & Operations Alnylam Pharmaceuticals

Jeff Axline is Executive Director, Supply Chain Strategy & Operations at Alnylam Pharmaceuticals. He leads teams responsible for global supply network strategy, logistics, trade compliance, and digital supply chain enablement, helping build a resilient and scalable supply chain that supports Alnylam's growing portfolio of RNAi therapeutics. Jeff brings extensive experience across supply chain planning, materials management, cold chain logistics, warehousing, supplier management, and SAP-enabled business processes, providing a broad perspective across both strategic supply chain design and operational execution.

Building the Future-Ready Pharma Supply Chain

3:00 PM Masterclass 5: Say Goodbye to the Control Tower: Alnylam's Three-Phase Bet on an Autonomous Cold Chain

Forget another panel discussion. This session opens with a live, high-stakes investigation: a temperature-sensitive shipment has landed, the clock is running, and you and your table have to answer two questions before time's up — was it late, and can it be released? Working the investigation, you'll chase evidence across logistics, quality, and transportation systems exactly the way cold chain teams do today, and feel firsthand why "we have a control tower" doesn't automatically mean "we have an answer."

Then Alnylam's Jeff Axline and PAXAFE's Chandler Williams walk you through what that exercise exposes, and what Alnylam is actually doing about it: a real, three-phase roadmap — from visibility, to a trusted system of record, to a 2028 vision of exception-based, auto-released quality decisions — grounded in the same fragmentation, latency, and missing-context problems you just lived through.

It's an unusually candid look at how one of the industry's most demanding cold chain shippers is thinking past the control tower toward genuinely autonomous, agentic supply chain decisions. If you're responsible for shipment visibility, quality release, or compliance at scale, this is the session where you'll see the next five years of that work mapped out.

Operationalizing Innovation: Delivering Future-Ready, Responsible, and High-Performing Supply Chains

1:20 PM Track C: Panel – Building Supply Chains from the Ground Up: How Biotechs Balance Speed, Risk & Limited Resources

Early-stage and emerging pharma companies must design supply chains that can support rapid growth, late-stage clinical milestones, and the transition to commercial production—all while operating with lean teams and limited infrastructure. This panel brings together biotech supply chain leaders to discuss how they build foundational processes, choose the right partners, manage risk with small volumes, and establish the capabilities needed for future scale.

Establish essential supply chain capabilities early, including forecasting, quality systems, material planning, logistics, and supplier management
Leverage partners strategically to close capability gaps without overbuilding internal teams too soon
Prepare for scale-up by designing flexible processes and networks that can grow with portfolio and demand complexity

Check out the incredible speaker line-up to see who will be joining Jeff.

Download The Latest Agenda